CELL SIGNALING (Elective 1) syllabus, JNTU (2007-2008)

UNIT I: INTRACELLULAR SIGNALING.

Introduction, Receptor-Ligand interactions.

UNIT II: ROLE OF RECEPTORS –I

Extra Cellular Receptors, Couplng to different signal transducing systems.

UNIT III : ROLE OF RECEPTORS –II

Type of intracellular receptors, steroid receptors, structure and function.

UNIT IV:SPECIFIC MOLECULES

Role and functions of G-proteins, CREB proteins, Calcium channels, second messengers-inositol, diacyl glycerol

UNIT V: MECHANISM

Signal transduction, mechanism and involvement of molecules.

UNIT VI: RECEPTORS

Regulations of receptor function,modification and adaptation of cells.

UNIT VII :PATHWAYS

Signal transduction pathways, applications in development and diseases.

UNIT VIII :ROLE OF DEFECTIVE SIGNALING

Development of abnormalities, signal transducing machinery as targets for potential drugs.

Textbooks

1. G.Posil and S.T. Crooke, Mechanism of receptor regulations, Plenum Press,1985.

2. R.H Getzenberg and E.E. Bittar, Cell structure and signaling, Elsevier Science, 1997.