IMMUNOLOGY syllabus, JNTU (2007-2008)

UNIT I: THE IMMUNE SYSTEM

Introduction, Phylogeny of the Immune system, Innate and acquired immunity. Immunochemistry: Immunogens, antigens, their chemical nature, Properties influencing immunogenicity, Haptens, adjuvants.

UNIT II: BIOLOGY OF THE IMMUNE SYSTEM

Cells of the IS: Haematopoiesis, lymphocyte leafficking, T, B, Macrophases, Dendritic cells, Natural killer cells, Eosinophils, Neutrophils, Mast cells and Phasocylosis.

UNIT III:ORGANS OF THE I.S. :

Primary and Secondary organs of I.S. (Thymus, Spleen, Lymphnode, lymphoid fo kicle, MALT, CALT, SALT

UNIT IV: HUMORAL IMMUNITY-I

B-lymphocytes, their lineage, Immunoglobulins, their structure function, classes, sub classes, genetic control of ab production. (Maturation of B cell) Isotype, allotypes, Idiotypes. Antigen-Antibody intereactions, hypersensitivity.

UNIT V: HUMORAL IMMUNITY -II

Activation of B cells, their differentiation and effector functions. Hybridoma Technology Monoclonal antibodies their application. Immunotoxing chimeric antibodies and abzymes.

UNIT VI: CELL MEDIATED IMMUNITY

T-cells subclasses their lineage, maturation TCR diversity, MHC, Ag processing and presentation, T-cell artivation, effector functions.

UNIT VII: Hypersensititvity

Hypersensitivity: Types of hypersensitivity, Principle, mechanisms their relevance & significance. Role of immune system in transplantation, autoimmunity, tumors.

UNIT VIII: Role of immune system in transplantation, autoimmunity, tumors

Transplantation- Graft rejection evidence and mechanisms of graft rejection ,prevention of graft rejection, immuno suppressive drugs, Autoimmunity – experimental models of autoimmune disease treatment of autoimmune disorders and Tumor immunology.

TEXT BOOKS:

1.E. Roitt Essential Immunology, Vaccines conventional, subunit and

recombinant, antidiotypic vaccine, Blackwell Scientific publications, Oxford,

1991.

2. Kuby Immunology, 5th Edition . Richard A Goldsby, Thomas J Kindt Barbara A

Osborne . W H Freeman and Company.

REFERENCES:

1. Benjamin E and Leskowitz S, immunology A short Course. Wiley LISS NY,

1991.ELISA Immunological Techniques. DNA vaccines Immunotechnology

2. Cellular Molecular Immunology. Abul Abbas and Litchman. 2003.