BIOPHARMACEUTICAL TECHNOLOGY Question Papers (Supple, Nov, 2008)

SET: 1

1. Describe the development of drug and pharmaceutical industries in India.

2. (a) Why are drugs referred to as xenobiotics? Explain. (b) What are soft drugs? Why are they considered safe (w.r.t the metabolites formed) and have short half life.

3. (a) What is meant by pharmacokinetics? What is its significance. (b) Give examples of zero-order rate processes.

4. What are the different types of reactions involved in the case of bulk drug manufacturing.

5. Write about different stages involved in sugar coating.

6. Write about different additives used for the development of parentals dosage forms.

7. Answer any three of the following:
(a) stimulant laxatives.
(b) hyperosmotic laxatives
(c) bulk forming laxatives
(d) Lubricant laxatives.

8. What are synthetic or non-steroidal esterogens? Describe about their importance and side effects?

SET: 2

1. What are antimalarial drugs? Give structure and uses of the following:
(a) quinine
(b) Trimethoprin
(c) Chloroquine
(d) Amodiaquine

2. Which physiochemical properties of the drug limit its distribution, describe in detail?

3. Why pharmacokinetic models are most important in the case of drug metabolism, explain in detail?

4. (a) Describe the laboratory filtration equipment and their usage? (b) What is cake filtration? Describe the cake filtration process in the bulk drug manufacturing industry.

5. Write about different stages involved in sugar coating?

6. Write about the different evaluation procedures for parental dosage forms.

7. Write the synthesis properties and used of ascorbic acid.

8. Write an account of different types of penicillins and write the structures, properties and uses of benzyl penicillin and phenoxymethyl penicillin.

SET: 3

1. (a) Describe the patents and designs act? Describe in brief the procedure for obtaining a patent? (b) what is meant by "piracy of registered design" and reciprocal arrangements under designs act? Define the term 'Patent' and 'invention'.

2. What are the characteristics of specialized transport systems? How can the kinetics of such processes may be described?

3. Why pharmacokinetics models are more important in the case of drug metabolism, explain in detail?

4. (a) How the pH is controlled in the manufacture of bulk drugs? Explain with examples.
(b) How the temperature is controlled in the case of bulk drug manufacturing, explain with examples.

5. (a) Write the advantages and disadvantages of the tablet dosage form. (b) Write about the manufacture of the tablets by direct compression.

6. Write about different glass containers used for the packing of dosage forms.

7. Write the synthesis properties and uses of ascorbic acid.

8. Write the types of non-steroidal oral contraceptives for women. Describe about their adverse effects, efficiency and failures.

SET: 4

1. (a) Describe the preventio of food Adulteration Act and Rules. (b) Answer any two of the following:
(i) central food on labratory
(ii) standards of quality
(iii) preservative in food artivle
(iv) coloring matter in food articles.

2. List the factors influencing protein binding of drugs?

3. (a) Define pharmacokinetics. Name and define the three pharmacokinetic parameters that describe a typical plasma level-time curve. (b) What are the various pharmacodynamic parameters?

4. (a) Write differences between batch mixing and continuous mixing. (b) What is the condensation reaction? How these reactions are useful in the bulk drug manufacturing process, explain with example.

5. Write about different stages involved in sugar coating.

6. Write about different glass containers used for the packing of dosage forms.

7. What are the water-soluble vitamins? Explain their properties and uses by taking some examples?

8. What are antibiotics? Discuss their chemical and mechanism based classification?