BIO INFORMATICS Question Papers (Supple, 2005)

SET : 1

1. What is HTTP? Explain about operation of HTTP? [16]

2. Explain about computational method for aligning DNA and Protein sequences?[16]

3. Define Multiple Alignment? Describe in detail about methods employed for Multiple sequence alignment? [16]

4. What is meant by Database Similarity searches? Explain different ways of Database similarity searching? [16]

5. Explain about Percent Accepted Mutation? [16]

6. Describe the following:
(a) Perfect phylogeny
(b) The relationship of Phylogenetic analysis and sequence alignment. [16]

7. Define Genome? Outline the structure and composition of prokaryotic and Eukaryotic genomes? [16]

8. What is a gene? Write the fine structure of the gene and compare the structural differences of gene between prokaryotes and eukaryotes? [16]

SET :2

1. Explain the steps involved in protein prediction and modeling by using Bioinformatics? [16]

2. Give an account of BLAST programs and how are they useful? [16]

3. Explain about Localized alignments in sequences? [16]

4. Describe the different databases available for the storage of protein information resources? [16]

5. Explain about Percent Accepted Mutation? [16]

6. Discuss about Concept of Trees in phylogenetic Analysis? [16]

7. Define Genome? Outline the structure and composition of prokaryotic and Eukaryotic genomes? [16]

8. Write short notes on:
(a) GRAIL II
(b) ORF [16]

SET :3

1. Describe the following:
(a) Uniform Resource Locator (URL)
(b) Role of Internet in Bioinformatics [16]

2. Definer Multiple sequence alignment? Describe in detail about methods employed in Multiple sequence alignment? [16]

3. Describe any one progressive method of multiple sequence alignment? [16]

4. How can you classify sequence databases? Describe about Nucleotide sequence databases? [16]

5. Explain about Pairwise database searching. [16]

6. Discus about relationships of Phylogenetic analysis to sequence alignment? [16]

7. Write an essay on sequence assembly and Gene Identification? [16]

8. Write short notes on:
(a) GRAIL II
(b) ORF [16]

SET :4
1. What is Bioinformatics? Describe its scope in modern biology? [16]

2. What type of scoring matrix is used by BLAST? Explain about different substitution matrices? [16]

3. What is multiple sequence alignment? Describe the applications of multiple se-quence alignments? [16]

4. Write in detail about DNA versus Protein searches? [16]

5. Write short notes on:
(a) BLOSUM
(b) Differentiate between PAM & BLOSUM [16]

6. Discus about relationships of Phylogenetic analysis to sequence alignment? [16]

7. What is DNA mapping? Describe its applications? [16]

8. Explain in detail about Feature based approaches to Gene Prediction? [16]