SET : 1
1. What is Bioinformatics? Describe its scope in modern biology?
2. Write short note on :
a) Dot plot
b) Local alignment
3. Write short notes on :
a) Relationship of multiple sequence alignment to phylogenetic analysis
b) Uses of multiple sequence alignment
4. Explain in detail about structural databases?
5. What is Block Substitution Matrices (BLOSUM)? Describe them in detail.
6. Describe the following :
a) Perfect phylogeny
b) The relationship of phylogenetic analysis and sequence assembly?
7. Discuss in detail about the steps involved in sequence assembly?
8. Write brief account on any two of the following :
a) Codov usage
b) Intron and exons
c) Regulatory sequences and their role.
SET : 2
1. Explain the steps involved in protein prediction and modeling by using bioinformatics?
2. Explain in detail about dynamics : Programming method for sequence alignment?
3. Give the general account on different common multiple sequence alignment methods?
4. Explain about BLAST sequence database search?
5. What is Block Substitution Matrices (BLOSUM)? Describe them in detail.
6. Describe the following :
c) Perfect phylogeny
d) The relationship of phylogenetic analysis and sequence assembly?
7. Define genome? Outline the structure and composition of prokaryotic and eukaryotic genomes?
8. Write short notes on :
a) GRAIL II
b) ORF
SET : 3
1. What is Bioinformatics? Describe its scope in modern biology?
2. Explain about computational method for aligning DNA and protein sequences.
3. What is multiple sequence alignment? Describe the applications of multiple sequence alignments?
4. Describe the following :
a) Structural classification of proteins
b) The CATH (Class, Architecture, Topology, Homology ) databases.
5. What is Block Substitution Matrices (BLOSUM)? Describe them in detail.
6. Define parsimony? Write in detail how parsimony is used to infer phylogenetic relationships?
7. Write short notes on :
a) Clone map
b) STS map
8. Write short notes on :
c) GRAIL II
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