BIOCHEMICAL REACTION ENGINEERING -II syllabus, JNTU (2007-2008)

UNIT I:BASIC CONCEPT

Definition of bioreactor, fundamental principles, Concept in energy and mass balances and in biological reaction modeling.

UNIT II:

Classification of reactors and their configurations, Application in submerged fermentation and solid state fermentation, classification based schuegerl, kafarov components of bioreactors and operation of bioreactors.

UNIT III: ANALYSIS OF IDEAL REACTORS

Concepts of reactors based on flow characteristics, design of ideal reactors using material and energy balance. Batch bioreactor design.

UNIT IV: CHEMOSTAT ANALYSIS

Definition of chemostat, turbidostat, single flow single stage chemostat, single flow multistage chemostat, recycle flow in chemostat, concepts of dilution rate productivity analysis.

UNIT V : PLUG FLOW REACTION SYSTEM

Plug flow behavior, design of plug flow reactor, comparison of productivity in plug flow and single stage single flow chemostat.

UNIT VI: NON-IDEAL BEHAVIOUR IN REACTION SYSTEMS

Reasons for non-ideality, concept of macro using –RTD analysis (E-C-F functions), diagnosing the ills of non-ideal bioreactors.

UNIT VII : DESIGN AND ANALYSIS OF ENZYME REACTORS

Application tubular reactor concept in immobilized packed bed reactors, fluidized bed reactors.

UNIT VIII: SPECIFIC BIOREACTORS ANALYSIS AND SCALE-UP

Design and analysis of fed-batch and air-lift bioreactors. Application in animal cell culture. Basic concept of scale-up, non-dimensional analysis.

Text Books:

1. O.Levenspiel, Chemical Reaction Engineering. 3^rd edition, Wiley Newyork,1992.
2. D.G.Rao, Introduction to Biochemical Engineering, McGraw-Hill,2005

3. H.Scott Fogler Elements of chemical reaction Engineering 3^rd edition ,Prentice-

Hall of India pvt ltd, 2004

References:

1. P.M.Doran Bioprocess Engineering Principles, Academic Press, 1995.

2. Jens Nielsen ,Johan villadsen,Gunnar liden, Bioreaction Engineering principles 2^nd edition springer 2007