UNIT I:INTRODUCTION TO COMPUTATIONAL MOLECULAR BIOLOGY
Introduction to active areas of research in Computational Molecular Biology, Functional Genomics, Comparative Genomics, Dynamic Programming, Graphical representation of biochemical systems, S-systems equations, steady state analysis, Model refinements
UNIT II : GENOMICS
DNA Sequence assembly and gene identification. Homology based gene prediction. SNPs and applications. Methods of studying gene expression, EST approach,
UNIT-III MICRO ARRAYS
Basics of Micro array
UNIT IV: PROTEOMICS I
Introduction to proteins. Protein identification, structure and function determination. Structure comparison methods. Prediction of secondary structure from sequence.
UNIT V: PROTEOMICS II
Protein homology modeling, Protein threading. Protein ab initio structure prediction. Protein design emphasis on structural Bioinformatics.
UNIT VI: TAXONOMY AND PHYLOGENY
Basic concepts in systematics, Molecular evolution, Definition and description of Phylogenetic trees and types of trees
UNIT-VII: DENDROGRAMS
Dendograms and its interpretation
UNIT-VIII: DRUG DESIGN
Drug discovery cycle, Role of Bioinformatics in Drug discovery
TEXT BOOKS:
1. David W Mount. Bioinformatics- Sequence and genome analysis. CSHL Press.
2. Jonathan Pevsner . Bioinformatics and Functional Genomics. A Jhon Wiely & Sons, Inc., Publication
3. E.O.Voit Computational Analysis of Biochemical systems, Cambridge University Press 2000.
REFERENCES:
1. Moody P C E and A J Wilkinson. Protein Engineering. IRL Press.
2. Creighton T E, Proteins. Freeman W H. Second edition 1993.
3. Journal BIOINFORMATICS (Oxford University).
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