BIOPHARMACEUTICAL TECHNOLOGY Elective-IV syllabus, JNTU (2007-2008)

UNIT I: INTRODUCTION TO PHARMACEUTICALS

History & Definition of Drugs. Sources of Drugs - Plant, Animals, Microbes and Minerals. Different dosage forms. Routes of drug administration.

UNIT II: PHARMACODYNAMICS

Physico-Chemical Principles, Pharmacodynamics- Mechanism of drug action, drug receptors, and Physiological receptors: structural and functional families.

UNIT III: PHARMACOKINETICS

Pharmacokinetics- Drug absortion, factors that affect the absortion of drugs, Distribution of drugs, Biotransformation of drugs, Bioavailability of drugs.

UNIT IV: DRUG MANUFACTURING PROCESSES I

Good manufacturing practices, manufacturing facilities, sources of Biopharmaceuticals,

UNIT V: DRUG MANUFACTURING PROCESSES II

Production & analysis of Biopharmaceuticals.

UNIT VI: PRODUCTION OF BIOPHARMACEUTICALS

Production of Therapeutic Proteins, Hormones, Cytokines - Interferons, Interleukins I & II, Tumor Necrosis Factor (TNF); Nucleic acids.

UNIT VII: APPLICATIONS OF BIOPHARMACEUTICALS

Role of Biopharmaceuticals in treatment of various health disorders

UNIT VIII: DRUG DELIVERY SYSTEMS, BIOMATERIALS AND THEIR APPLICATIONS

Controlled and sustained delivery of drugs. Biomaterial for the sustained drug delivery. Liposome mediated drug delivery. Drug delivery methods for therapeutic proteins.

Reference:

1. Biopharmaceuticals: Biochemistry & Biotechnology, Gary Walsh (1998), John Wiley &

Sons Ltd.

2. Remington’s Pharmaceutical sciences, (Mark Publications & Company eston PA ) year 1980.

3. Theory & Practice of Industrial Pharmacy, (3rd ed.) Leon Lachman, Lea &

Febiger (1986)