UNIT I: FUNDAMENTALS OF CANCER BIOLOGY
Regulation of Cell cycle, mutations that cause changes in signal molecules, effects on receptor, signal switches,
UNIT II: TUMOR SUPPRESSION
tumour suppressor genes, modulation of cell cycle in cancer. Different forms of cancers, Diet and cancer.
UNIT III: PRINCIPLES OF CARCINOGENESIS I
Chemical Carcinogenesis, Metabolism of Carcinogenesis, Natural History of Carcinogenesis, Targets of Chemical Carcinogenesis
UNIT IV: PRINCIPLES OF CARCINOGENESIS II
Principles of Physical Carcinogenesis, X - Ray radiation - mechanism of radiation Carcinogenesis.
UNIT V: MOLECULAR CELL BIOLOGY OF CANCER
Oncogenes, Identification of Oncogenes, Retroviruses and Oncogenes, detection of Oncogenes, Growth Factor and Growth Factor receptors that are Oncogenes. Oncogenes / Proto Oncogene activity. Growth factors related to transformations.
UNIT VI: PRINCIPLES OF CANCER METASTASIS
Clinical significances of invasion, heterogeneity of metastatic phenotype, Metastatic cascade, Basement Membrane disruption, Three-step theory of Invasion, Proteinases and tumour cell invasion.
UNIT VII: DETECTION OF CANCER
Detection of Cancers, Prediction of aggressiveness of Cancer, Advances in Cancer detection.
UNIT VIII: NEW MOLECULES FOR CANCER THERAPY
Different forms of therapy, Chemotherapy, radiation Therapy, and Immuno therapy: advantages and limitations.
TEXT BOOKS
1. Maly B.W.J. Virology a practical approach, IRL Press, Oxford, 1987.
2. Scientific Publications. Oxford, 1988.An Introduction to Cellular and Molecular Biology of Cancer, Oxford Medical publications, 1991.
REFERENCE:
0 comments:
Post a Comment