GENETICS Question Papers

SET 1 :

1. Differentiate between test cross and back cross with example.

2. What is the evidence that the genetic material of TMV ( Tobacco Mosaic Virus) is RNA.

3. How you define the co-relationship between linkage vs. Independent assortment?

4. Describe the mechanism of transduction process.

5. What is karyotyping? What it is used in relation to diseases?

6. Focus light on the molecular basis of mutations.

7. Contrast the Nnotch locus with the Bar locus in Drosophila. What phenotypic ratio would be produced in a cross between Notch females with Bar male.

8. What do you mean by extra chromosomal inheritance? Write an example how it transfers to next generation.

SET 2 :

1. Describe the inheritance of a quantitative trait with suitable examples.

2. Write in detail about the organization of bacterial genome.

3. Draw differences between linkage and crossing over.

4. Describe the mechanism of transformation process.

5. What are nucleosomes? Focus light on their structural organization.

6. Give an account of spontaneous mutations? Describes their significance.

7. Relate the potential effect of the Lyon hypothesis on the retina of a human female heterozygous for the X-linked red-green color-blindness.

8. What genetic tests could you conduct to show that the mate killer phenotype in paramecium requires a dominant allele at any one of two loci?

SET 3 :

1. How are penetrance and expressivity related?

2. Several years after Griffith described the transferring principle, Avery, Mc Leod and Mc Carty investigated the same phenomenon.

a) Describe their experiments.

b) What did their experiments demonstrate beyond Griffith’s?

3. Describe the experiment of Creighton and Mc Clintock that demonstrated that recombination involved a physical exchange of chromosomal material?

4. Describe the origin of F’bacteria and merozygotes.

5. Poletene chromosome have proved to be an extremely useful tool for the analysis of DNA organization. Explain the statement with structure of poletene chromosome.

6. Differentiate between point mutations that re transitions versus transversions. Using the DNA bases(A,T,G and C) list the four types of transition and the eight types of transversions.

7. Define lyon hypothesis.

8. Give the genotypes involved when a sinistral female snail produces dextral offspring. What genotypes could the male parent of the sinistral female have?

SET 4 :

1. What is the difference between epistasis and pleiotropy?

2. Why were 32 P and 35 S chosen for use in the Hershey-Chase experiment? Discuss the rationale and conclusions of these experiments.

3. Describe between single cross over and multiple crossover?

4. Describe the mechanism of transformation process.

5. Explain about paracentric and pericentric inversion.

6. Briefly describe physical, chemical and biological methods of developing new mutations.

7. Relate the potential effect of the Lyon hypothesis on the retina of a human female heterozygous for the X-linked red-green color-blindness.

8. What genetic criteria distinguish a case of extrachromosomal inheritance from a case of Mendelian autosomal inheritance?