UNIT-I
Application of Engineering principles in biotech Industries-Introduction to unit operations and unit processes–application of transport phenomenon principles (momentum, mass and heat transfer) in bioprocessing.
UNIT-II
Units and dimensions, basic quantities and derived units. Conversion of units. Concept of mass and force, definition of gc and its utility. Various equations of state including ideal gas law to evaluate P-V.T data, their application in process calculations by solving basics numerical problems.
UNIT-III
Fluid mechanics- Properties of fluids, fluid statics, energy balance in fluid flow through pipes and condunits, Bernoulli’s equation and its application, calculation of power required for pumping fluids. Examples from bioprocessing systems .
UNIT-IV
Rheology of fluids - Newton’s law of viscosity. Concept of Newtonian and non - Newtonian fluids- Different types of non-Newtonian fluids with examples in bioprocessing. Measurement of viscosity using extrusion rheometer, plate and cone viscometer, coaxial cylinder viscometer.
UNIT-V
Flow through pipes, average velocity, flow regimes, boundary layer concept. Laminar and turbulent flow – characterization by Reynold’s number, pressure drop due to
skin friction and form friction, friction factor chart, Hagen -Poiseuille equation. Brief introduction to flow of compressible fluids.
UNIT-VI
Flow past immersed bodies: Definition of drag and drag coefficient. Friction in flow through beds of solids, derivation of friction factor equations and pressure drop expressions. Introduction of the concept of packed beds. Motion of particles through fluids, terminal velocity.
UNIT-VII
Flow measuring and monitoring systems- valves, bends, elbows, prevention of leaks, mechanical seals, stuffing box. Flow measuring devices-manometers, orifice meter, venture meter and rotameter.
UNIT-VIII
Fluid transportation machinery: Different types of pumps, positive displacement pumps, reciprocating pumps, diaphragm pumps, peristaltic pumps. Calculation of pump horse power.
TEXT BOOKS:
1. Introduction to Biochemical Engineering, D.G.Rao, Tata Mc Hill (2005)
2. Bio-process Engineering Principles, Pauline M.Doran. Academic press (1995)
3. Unit operations of chemical engineering,Mc Cabe, W.L, Smith J.C., and Harriot P., Mc-Graw Hill, 3rd Ed. (1993).
REFERENCES:
1. “Technical aspects of the rheological properties of microbial cultures“, - Charles,
M (1978) in Advanmces in Biochemical Engineering, Ghose, T.K., Fiechter, A
and Blakebrough, N.(Eds), Spinger-Verlag, Berlin, pp. 1-62
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