BIOCHEMISTRY syllabus, JNTU (2007-2008)

UNIT I: CARBOHYDRATE STRUCTURE & FUNCTION

Structure and properties of Mono, Di, Oligo & polysaccharides, complex carbohydrates, Confirmation of pyranose & furanose ring, glycosidic bond, Glycogen, starch & dextran; as mobilizable stores of glucose. cellulose, glycoproteins, glycosaminoglycans & lectins;

structure and function.

UNIT II: BASIC CONCEPTS OF ENZYMES

Introduction to Enzymes, Nomenclature, Functions, Mechanism of action and control , Michaelis – Menten Enzymes and Allosteric Enzymes

UNIT III CARBOHYDRATE METABOLISM

Glycolysis, Glucogenesis, Glycogenolysis, Gluconeogenesis, ED Pathway, Pentoses phosphate shunt & TCA cycle

UNIT IV : BIOENERGETICS

Respiratory chain, Aerobic and anaerobic respiration.

UNIT V: PROTEINS & AMINO ACIDS METABOLISM -I

Amino acids - Classifications, Physico – Chemical Properties, Protein structure, folding & function, Nitrogen Cycle, Nitrogen Balance, reductive amination & transamination &Urea cycle.

UNIT VI : PROTEINS & AMINO ACIDS METABOLISM -II

Synthesis of amino acids - Glutamate pathway; Serine pathway; shikimate pathway for the production of aromatic amino acids.

UNIT VII: LIPIDS & THEIR METABOLISM

Classifications, Structures and roles of fatty acids; fatty acid breakdown; fatty acid synthesis; synthesis and metabolism of triglycerols, cholesterol structure and function. Lipoproteins – classification & function.

UNIT VIII: INTERMEDIARY METABOLISM

Interconnection of pathways & metabolic regulation

NUCLEIC ACIDS AND THEIR METABOLISM

Structure and Properties of purines, pyrimidines, Nucleosides and Nucleotides. Biosynthesis and degradation of nucleic acids

TEXT BOOKS:

1. Lehninger A.L, Nelson O.’L, M.M. Cox, Principles of Biochemistry 3^rd Edition, 2000 CBS

Publications, 1993. ,

2. Fundamentals of Biochemistry J.L. Jain S. Chand Publishers

REFERENCES:

1. Voet D, Voet J. G, Biochemistry, Second Edition, John C Wiley and Sons, 1994.

2. L. Stryer, J.M. Berg, JL Tymockzo Biochemistry 5^th edition, WH Freemen & Co 2002.

3. Biochemistry by K. Mathews, K.E. Van Holde, Kevin G Ahern, Pearson education.

4. Protein’s Structure and function. Daviel Whitford John Wiley Publications.

5. Biochemistry by cristopher K.Mathews, K.E.Van Holde, Pearsons education.