THERMODYNAMICS FOR BIOTECHNOLOGISTS syllabus, JNTU (2007-2008)

UNIT I: BASIC CONCEPTS IN ENGINEERING THERMODYNAMICS

First and Second law of thermodynamics; Calculation of Work, energy and property changes in reversible processes, Thermodynamics of flow processes; Power cycles and refrigeration cycles, Residual properties

UNIT II: MATERIAL BALANCE

Steady state and equilibrium, types of material balances, stoichiometry of growth and product formation, Electron balance, Theoretical oxygen demand

UNIT III: ENERGY BALANCES

Basic Energy concepts, Intensive and Extensive properties, general energy balance equations, Enthalpy calculations, State properties-reactive and non-reactive systems, Heat of solutions, Heat of combustion, Heat of reaction in non-standard condition; Energy balance equation for cell culture with basic numerical calculations.

Unit IV:UNSTEADY-STATE MATERIAL AND ENERGY BALANCES

Unsteady state material balance and energy balance equations; Solving unsteady equations for biological systems in CSTR, fed-batch and plug flow reactors.

Unit V:THERMODYNAMIC PROPERTIES OF FLUIDS

Estimation of thermodynamic properties using equations of state; Maxwell relationships and their applications; Calculation of flow processes based on actual property changes

UNIT VI: SOLUTION THERMODYNAMICS

Partial molar properties; concepts of chemical potential and fugacity Ideal non ideal solutions; Gibbs Duhem equation; Excess properties of mixtures; Activity Coefficient - corm position models

UNIT VII: PHASE EQUILIBRIA

Criteria for phase equilibrium; Vapour-liquid equilibrium calculations for binary mixtures, liquid -Liquid equilibrium and Solid-liquid equilibrium

UNIT VIII: CHEMICAL REACTION EQUILIBRIA

Equilibrium criteria for homogeneous chemical reactions; Evaluation of equilibrium constant and effect of pressure and temperature on equilibrium constant; Calculation of equilibrium conversions and yields for single and multiple chemical reactions

TEXT BOOKS :

1. J M.Smith,H.C.Van Ness and M.M.Abbott. Introduction to Chemical Engineering

Thermodynamics McGraw Hill

2.P.M.Doaran,Bioprocess Engineering Principles, Academic Press,1995.

REFERENCES:

M.D.Koretsky, Engineering and Chemical Thermodynamics, John Wiley and sons,2004