PHARMACEUTICAL CHEMISTRY - MEDICINAL-II Question Papers 4 A.U

Answer question no.1(compulsory) and any four of the remaining. All questions carry equal marks

1. Explain the importance of sterioisomerism in the biological activity of drugs giving suitable examples.

2. Classify Sulphonamides giving structure of important members. Write the SAR, mode of action and side effects. Explain the importance of Pka in the desigh of safer sulfa drugs.

3. Enumerate antileprotic agents giving structures of important drugs. Write the SAR and mode of action of sulfonates. Outline the synthesis of Clofazimine and Dapsone.

4. Classify antihypertensive giving structures of one drug for each class. Write the SAR of b-adrenergic blockers and ACE inhibitors. Outline the synthesis of any one important member.

5. (a) Explain about prodrugs and soft drugs giving examples.
(b) Write a brief note on:

• Chemotherapeutic index
• Superinfection

6. (a) Discuss the factors affecting absorption of drugs. (b) Write notes on antiamoebic agents.

7. Classify antimalarials giving examples write the SAR and mode of action of aminoqunolines. Outline the synthesis of Mepacrine.

8. Give an account of :

• Carbonic anhydrase inhibitors
• Aalkylating agents
• Cholinergic agonists