BIOMATERIALS (ELECTIVE – III)
UNIT I
Properties of Materials. Classes of materials used in medicine: Metals, Polymers, Hydrogels Bioresorbable and Biodegradable Materials, Ceramics, Natural materials composites thin films, grafts, Coatings medical fibers and Biological functional materials, Smart materials, Pyrolytic Carbon for long-term medical Implants textured and Porous materials non-fouling surfaces
UNIT-II
Host reactions to : Inflammation, Wound healing and the Foreign body response.
Systemic toxicity and Hypersensitivity. Blood coagulation and Blood-materials Interactions. Tumorigenesis.
UNIT-III
Testing biomaterials:In Vitro assessment of tissue compatibility In vivo assessment of tissue compatibility. Testing of blood-materials interactions.
Degradation of materials in the biological environment: Effects of the Biological environment on metals, polymers and ceramics.
UNIT-IV
Applications of materials in medicine, Dentistry and Biology: Cardiovascular medical devices. Nonthrombogenic treatments and Strategies. Dental implantation adhesive and Sealants. Ophthalmologic applications-intraocular lens implants.
UNIT-V
Orthopedic biomaterials, Performance of drug delivery systems, Sutures. Burn dressings and Skin substitutes.
UNIT-VI
Artificial organs and tissues: Implantable cardiac assist devices. Materials for extracorporeal devices. Cochlear implants. Artificial red blood cell substitutes.
UNIT-VII
Sterilization of implants and Devices implants and Device failure. Surface properties with Biological responses. Implant retrieval and Evaluation.
UNIT-VIII
Standards development and regulation of medical products using biomaterials. Nano bio materials.
TEXT BOOKS:
1. Biomaterials Science: An Introduction to Materials in Medicine Buddy D. Ratner, Frederick J. Schoen, Allan S. Hoffman, Jack E. Lemons
2. Hench L L Ethridgc E.C. Biomaterials, an interfacial approach, Academic press 1982
REFERENCE:
1. Bronzino J D, the biomedical engineering handbook CRC Press
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