BIO INFORMATICS Question Papers (Regular, 2007)

SET : 1

1. Write short notes on the following :

a) Domain and domain name

b) Modem

c) Routers

d) FQDN

2. What types of scoring matrix is used by BLAST? Explain about different substitution matrices?

3. Explain in detail about the databases of multiple alignments?

4. Write an assay on different genome (DNA) information resource?

5. Who created BLAST and explain the type of scoring matrix used by BLAST?

6. Discuss about relationships of phylogenetic analysis to sequence alignment?

7. What are genomic MAP elements? Explain about different types of Maps?

8. What is a gene? Write the fine structure of the gene and compare the structural differences of gene between prokaryotes and eukaryotes?

SET : 2

1. What is telnet? Explain its functioning system?

2. What is meant by similarity searching? Explain in detail about sequence similarity search tools?

3. What is multiple sequence alignment? Describe the applications of multiple sequence alignments?

4. Describe the following :

a) Structural classification of proteins

b) The CATH (Class, Architecture, Topology, Homology ) databases.

5. What is Block Substitution Matrices (BLOSUM)? Describe them in detail.

6. Explain the significance of phylogenetic analysis in inferring the relationship between distantly related sequences?

7. Describe the steps involved in sequence assembly?

8. Write short notes on :

a) Contant based methods

b) Comparative methods

c) Central dogma in gene expression.

SET : 3

1. Explain the steps involved in protein prediction and modeling by using Bioinformatics?

2. What are Direct and Inverted repeats? Suggest a comparision method for knowing direct and inverted repeats and explain about it?

3. Write short notes on :

a) CLUSTAL W

b) PILEUP

4. What is meant by database similarity searches? Explain different ways of database similarity searching?

5. What is Block Substitution Matrices (BLOSUM)? Describe them in detail.

6. What are ultra metric trees and distances? Describe them in detail.

7. What are the important problems that will be encountered in sequencing and explain about them?

8. Write short notes on :

a) GRAIL II

b) ORF

SET : 4

1. What is Bioinformatics? Describe its scope in modern biology?

2. Explain about different BLAST programs in detail with a neat flow chart and how are they useful?

3. Define Multiple Alignments? Describe in detail methods employed for Multiple sequence alignment?

4. Explain about FASTA sequence database similarity searching?

5. Describe the different BLAST suits used to search DNA and protein databases.

6. Discuss in detail about character based methods in phylogenetic analysis?

7. Define gene mapping? Explain about applications of mapping?

8. Write short notes on :

c) GRAIL II

d) ORF