SET : 1
- What is cancer? Explain different factors that are involved in the cancer development?
- Discuss a) RB, retinivlastoma b) p53
- What is a carcinogen? Expain different types of carcinogens in the development of cancer?
- What is signal transduction? Explain the effects on the cell-cell signaling during the radiation carcinogenesis?
- Write short notes on: a) cell cycle check points b) Cancer genes
- Explain : a) Role of Plasma membrane components in metastatis. b) Role of extracellular matrix components and the basement membranes in tumor metastatis.
- Can the gene expression patterns of cancer cells be used to identify targets for cancer diagnosis or therapy? - discuss.
- Write short notes on : a) Recombinant anticancer drugs. b) Problems of antibody therapy in cancer.
- What are receptors? Explain the ligand-receptor mechanism with an example?
- Explain a) Skin Cancer b) Colon cancer
- Define a) DNA adduct b) DNA repair c) p53 gene d) cyt P450.
- Discuss : a) cellular stress response b) Gene induction during radiation exposure.
- Write short notes on a) Retroviral transduction. b) Amplification of Oncogene action.
- Explain : a) Tissue adhesion properties of metastatic cells b) Ability of metastatic tumor cells to escape the hosts immune response.
- Write short notes on : a) combination therapies. b) cancer diagnosis and staging
- Discuss : a) Recent developments in cancer therapy. b) New drugs, New targets and new approaches of cancer.
- Explain a) Oncogenes b) Receptors c) Signaling molecules.
- What is the role of diet in different forms of cancer?
- What are mutations? Explain how Chemical carcinogens play a role in the development of mutations?
- Define and discuss: a) Units of Radiation b) Radiation Dose
- Write short notes on : a) Angiogenesis b) Tumor viruses and cancer
- Explain a) Chemotactic factors in cancer cell migration. b) Role of Oncogenes in tumor metastatis
- Write short notes on: a) Safety and acceptability of screening tests of cancer b) Evaluation of cancer screening.
- Explain a) Assessing efficacy of drugs in clinical trials. b) cells as vehicles for cancer gene therapy.
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