SYLLABUS 4 JNTU BME - BIOFLUIDS AND MECHANICS

BIOFLUIDS AND MECHANICS

UNIT-I
BIO-FLUID MECHANICS: Newton’s laws, Stress, Strain, Elasticity, Hooks-law, viscosity, Newtonian fluid, Non- Newtonian fluid, Viscoelastic fluids, vascular tree, Relationship between diameter, velocity and Pressure of blood flow, Resistance against flow.

UNIT-II
FLOW PROPERTIES OF BLOOD: Physical chemical and Rheological properties of blood. Apparent and relative viscosity, Blood viscosity variation: Effect of shear rate, hematocrit, temperature, protein contents of blood. Casson’s equation, Problems associated with extracarporeal blood flow.

UNIT-III
RHEOLOGY OF BLOOD IN MICROVESSELS: Fahraeus -Lindquist effect and inverse effect, distribution of suspended particles in a narrow rigid tube. Nature of red cells in tightly fitting tubes, hematocrit in very narrow tube

UNIT-IV
BIOVISCOELASTIC FLUID: Viscoelasticity, Viscoelastic models Maxwell, Voigt and Kelvin Models, Response to Harmonic variation, Use of viscoelastic models Bio- Viscoelastic fluids: Protoplasm, Mucus, Saliva, Synovial fluids.

UNIT-V
CARDIAC MECHANICS: Cardiovascular system. Mechanical properties of blood vessels: arteries, arterioles, capillaries and veins.
Blood flow: Laminar and Turbulent, Physics of cardiovascular diseases, Prosthetic heart valves and replacements.

UNIT-VI
RESPIRATORY MECHANICS: Alveoli mechanics, Interaction of Blood and Lung P.V curve of Lung. Breathing mechanism, Airway resistance, Physics of Lung diseases.

UNIT-VII
SOFT TISSUE MECHANICS: Pseudo elasticity, non-linear stress-strain relationship, Viscoelasticity, Structure, function and mechanical properties of skin, ligaments and tendons.

UNIT-VIII
ORTHOPEDIC MECHANICS: Mechanical properties of cartilage, diffusion properties of Articular cartilage, mechanical properties of bone, kinetics and kinematics of joints, lubrication of joints.

TEXT BOOKS:
1. Y.C Fung, Biomechanics- Mechanical properties of living tissues,2nd ed, Springer-Verlag, 1993.
2. D.O Cooney, Biomedical engineering Principles. Marcel Dekker, INC New York.1976.

REFERENCE:
1. Silver Frederick H. Biomaterials, Medical Devices & Tissue Engineering: Chapman & Hall, London, 1994
2. Biomechanics by Nihanth ozkai
3. D.A Mc Donald, Blood flow in arteries, Edward Arnold ltd, 1998.